Description
Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed: 26823428). Mediates the transport of chloride ions across the cell membrane (PubMed: 10792060, PubMed: 11524016, PubMed: 11707463, PubMed: 12519745, PubMed: 15010471, PubMed: 12588899, PubMed: 17036051, PubMed: 19398555, PubMed: 19621064, PubMed: 22178883, PubMed: 25330774, PubMed: 1712898, PubMed: 8910473, PubMed: 9804160, PubMed: 12529365, PubMed: 17182731, PubMed: 26846474, PubMed: 28087700). Channel activity is coupled to ATP hydrolysis (PubMed: 8910473). The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration (PubMed: 15010471, PubMed: 19019741). Exerts its function also by modulating the activity of other ion channels and transporters (PubMed: 12403779, PubMed: 22178883, PubMed: 22121115, PubMed: 27941075). Plays an important role in airway fluid homeostasis (PubMed: 16645176, PubMed: 19621064, PubMed: 26823428). Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens (PubMed: 14668433, PubMed: 16645176, PubMed: 26823428). Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex (PubMed: 17434346, PubMed: 27941075, PubMed: 17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed: 17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed: 27941075). May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 (PubMed: 12403779). Can inhibit the chloride channel activity of ANO1 (PubMed: 22178883). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed: 19923167, PubMed: 27714810)